Polyarteritis Nodosa

necrotizing vasculitis.
- - Others
    - Churg-Strauss syndrome,
    - microscopic PAN,
    - Kawasaki disease,
    - rheumatoid vasculitis,
    - Wegener granulomatosis, and
    - hypersensitivity vasculitis
medium or small caliber arteries – occasionally small veins
Cause
- - M:F .2:1
  - 5th–7th decades.
    - immune complex deposition
      - hepatitis B virus HIV
necrosis and destruction of the walls of vessels.
- - kidneys70-80%
  - heart spleen lung – rare
diagnosis
- - clinical symptoms and laboratory data,
  - biopsy
  - angiogram provides the proof in some cases.
    - microaneurysms in medium or small arteries.
    - stenosis
    - occlusion